Symbol
Name
ID

Cd44
CD44 antigen
MGI:88338

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

decreased activation-induced cell death of T cells

abnormal osteoclast differentiation

abnormal leukocyte migration

impaired leukocyte tethering or rolling

abnormal leukocyte adhesion

decreased T cell proliferation

impaired macrophage phagocytosis

peritoneal inflammation

decreased mast cell number

decreased mast cell histamine storage

decreased central memory CD4-positive, alpha-beta T cell number

decreased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

decreased central memory CD8 positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased alpha-beta T cell number

abnormal CD4-positive, alpha beta T cell morphology

abnormal CD8-positive, alpha beta T cell morphology

abnormal neutrophil physiology

impaired neutrophil recruitment

impaired natural killer cell mediated cytotoxicity

abnormal CD4-positive, alpha-beta T cell physiology

abnormal T-helper 1 physiology

abnormal T-helper 2 physiology

abnormal circulating cytokine level

abnormal circulating chemokine level

increased circulating interferon-gamma level

increased circulating interleukin-2 level

decreased circulating tumor necrosis factor level

increased circulating tumor necrosis factor level

decreased susceptibility to type IV hypersensitivity reaction

abnormal chemokine secretion

abnormal interleukin secretion

increased interleukin-1 beta secretion

increased interleukin-10 secretion

increased interleukin-6 secretion

increased tumor necrosis factor secretion

decreased susceptibility to experimental autoimmune encephalomyelitis

decreased susceptibility to induced arthritis

increased susceptibility to induced arthritis

decreased acute inflammation

increased acute inflammation

liver inflammation

lung inflammation

abnormal response to infection

increased susceptibility to parasitic infection

Availability

Mouse Genotype

Cd44^M1Btlr/Cd44^M1Btlr

Cd44^tm1.1Ugu/Cd44^tm1.1Ugu

Cd44^tm1Hbg/Cd44^tm1Hbg

Cd44^tm1Mak/Cd44^tm1Mak

Cd44^tm1Ugu/Cd44^tm1Ugu

Cd44^tm2.1Ugu/Cd44^tm2.1Ugu

Cd44^tm2Kmz/Cd44^tm2Kmz

Cd44^tm1Mak/Cd44⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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